Treatment of Non-gonococcal Urethritis with 5-iodo-2'-deoxyuridine.
نویسنده
چکیده
5-iodo-2'-deoxyuridine (5IDU) is an antiviral compound which has a chemical composition closely resembling that of thymidine; the antiviral effect is thought to be due to the metabolic antagonism to the uptake of thymidine in the deoxyribonucleic acid (DNA) molecule (Prusoff, 1959). This molecule combined with protein is the main composition of the herpes simplex virus, upon the metabolism of which the effects of this drug have so far been mainly studied. The similarity in the molecular configuration of thymidine and 5-iodo-2'-deoxyuridine is shown in the Figure.
منابع مشابه
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ورودعنوان ژورنال:
- The British journal of venereal diseases
دوره 40 شماره
صفحات -
تاریخ انتشار 1964